Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytochrome P450 2D6 genotype-phenotype characterization through population pharmacokinetic modeling of tedatioxetine.

CPT: pharmacometrics & systems pharmacology - 1 Sept 2021

Frederiksen Trine, Areberg Johan, Schmidt Ellen, Stage Tore Bjerregaard, Brøsen Kim

Abstract excerpt

The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack of consensus on how to translate genotypes into phenotypes, causing inconsistency in genotype-based dose recommendations. The aim of this study was to quantify and compare the impact of different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Antidepressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clinical Trials, Phase I as Topic

Share to Clinical Trials, Phase II as Topic

Share to Cytochrome P-450 CYP2D6

Share to Models, Biological

Share to Piperidines

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 33932135
DOI: 10.1002/psp4.12635
PMCID: PMC8452298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytochrome P450 2D6 genotype-phenotype characterization through population pharmacokinetic modeling of tedatioxetine.PMID 33932135Read ↗

Quantification of In Vivo Metabolic Activity of CYP2D6 Genotypes and Alleles Through Population Pharmacokinetic Analysis of Vortioxetine.Semantic proximity Read ↗

Using population pharmacokinetic analyses of drugs metabolized by CYP2D6 to study the genotype-phenotype translation.Semantic proximity Read ↗

Estimating the In Vivo Function of CYP2D6 Alleles through Population Pharmacokinetic Modeling of Brexpiprazole.Semantic proximity Read ↗

Does ethnicity impact CYP2D6 genotype-phenotype relationships?Semantic proximity Read ↗

Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates.Semantic proximity Read ↗

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine.Semantic proximity Read ↗

CYP2D6*11 and challenges in clinical genotyping of the highly polymorphic CYP2D6 gene.Semantic proximity Read ↗

Pharmacogenetics: the molecular genetics of CYP2D6 dependent drug metabolism.Semantic proximity Read ↗

Substrate specificity of CYP2D6 genetic variants.Semantic proximity Read ↗

Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms.Semantic proximity Read ↗

Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.Semantic proximity Read ↗

CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.