Article
The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population.
European journal of clinical pharmacology - 1 May 2000
Fukuda T, Nishida Y, Zhou Q, Yamamoto I, Kondo S, Azuma J
Abstract excerpt
OBJECTIVE: The cytochrome P450 isozymes CYP2D6 and CYP2C19 exhibit genetic polymorphism in human, including a marked interethnic difference. As the functional status of the isozymes CYP2D6 and CYP2C19 have an impact on the pharmacokinetics of some antidepressants, we investigated whether the disp...
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