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Article

Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone.

Archives of pharmacal research - 1 Jan 2023

Cho Chang-Keun, Byeon Ji-Young, Kang Pureum, Park Jung-In, Jang Choon-Gon, Lee Seok-Yong, Choi Chang-Ik, Bae Jung-Woo, Lee Yun Jeong

Abstract excerpt

Tolperisone, a muscle relaxant used for post-stroke spasticity, has been reported to have a very wide interindividual pharmacokinetic variability. It is metabolized mainly by CYP2D6 and, to a lesser extent, by CYP2C19 and CYP1A2. CYP2D6 is a highly polymorphic enzyme, and CYP2D6*wt/*wt, CYP2D6*wt/*10 and CYP2D6*10/*10 genotypes constitute more than 90% of the CYP2D6 genotypes in the Korean population. Thus,...

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PMID: 36542291
DOI: 10.1007/s12272-022-01422-1

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