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Article

Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects.

British journal of clinical pharmacology - 1 Nov 2008

Lim Kyoung Soo, Cho Joo-Youn, Jang In-Jin, Kim Bo-Hyung, Kim JaeWoo, Jeon Ji-Young, Tae Yu-Mi, Yi SoJeong, Eum SoYoung, Shin Sang-Goo, Yu Kyung-Sang

Abstract excerpt

AIMS: The objectives were to evaluate the effect of CYP2D6 genetic polymorphism on the pharmacokinetics of flecainide, and also on the extent of drug interaction with paroxetine as a CYP2D6 inhibitor after a single oral administration in healthy subjects. METHODS: An open-label, two-period, single-sequence, cross-over study was performed in 21 healthy Korean male volunteers (seven for CYP2D6*1/*1 or *1/*2, group...

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Identifiers

PMID: 18754843
DOI: 10.1111/j.1365-2125.2008.03267.x
PMCID: PMC2661981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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