Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes.

doi:10.1016/S0009-9236(98)90069-8

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Article

Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes.

Clinical pharmacology and therapeutics - 1 Oct 1998

Yue Q Y, Zhong Z H, Tybring G, Dalén P, Dahl M L, Bertilsson L, Sjöqvist F

Abstract excerpt

OBJECTIVES: To study the impact of the CYP2D6*10 allele on the disposition of nortriptyline in Chinese subjects. METHODS: A single dose of 25 mg nortriptyline was given orally to 15 healthy Chinese volunteers who were classified as extensive metabolizers after phenotyping with debrisoquin (INN, d...

Topics

Adult
Antidepressive Agents, Tricyclic
Asian People
China
Cytochrome P-450 CYP2D6
Female
Gas Chromatography-Mass Spectrometry
Genotype
Humans
Hydroxylation
Male
Middle Aged
Nortriptyline
Polymerase Chain Reaction
Sweden

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Identifiers

PMID: 9797795
DOI: 10.1016/S0009-9236(98)90069-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9797795-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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