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Article

Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes.

Clinical pharmacology and therapeutics - 1 Oct 1998

Yue Q Y, Zhong Z H, Tybring G, Dalén P, Dahl M L, Bertilsson L, Sjöqvist F

Abstract excerpt

OBJECTIVES: To study the impact of the CYP2D6*10 allele on the disposition of nortriptyline in Chinese subjects. METHODS: A single dose of 25 mg nortriptyline was given orally to 15 healthy Chinese volunteers who were classified as extensive metabolizers after phenotyping with debrisoquin (INN, debrisoquine) and who were genotyped by allele-specific polymerase chain reaction. Five subjects were homozygous for...

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Identifiers

PMID: 9797795
DOI: 10.1016/S0009-9236(98)90069-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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