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Article

Molecular basis of action of HyBeacon fluorogenic probes: a spectroscopic and molecular dynamics study.

Journal of biomolecular structure & dynamics - 1 Aug 2005

Marks Abigail H R, Bhadra Pranab K, McDowell David G, French David J, Douglas Kenneth T, Bichenkova Elena V, Bryce Richard A

Abstract excerpt

HyBeacons, novel DNA probes for ultra-rapid detection of single nucleotide polymorphisms, contain a fluorophore covalently attached via a linker group to an internal nucleotide. As the probe does not require a quencher or self-complementarity to function, this study investigates the molecular-level mechanism underlying the increase of fluorescence intensity on hybridization of HyBeacons with target DNA....

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Identifiers

PMID: 15918676
DOI: 10.1080/07391102.2005.10507046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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