Article

Fundamentals on the Kinetic and Thermodynamic Analysis of Oligonucleotide DNA Hybridization by Surface Plasmon Resonance: A Guide for HIF1α Antisense Design

2026-08-11

Abstract excerpt

Antisense oligonucleotides (ASO) are nucleotide polymers that hybridize to sense strands and have been successful in treating a variety of diseases. A wide range of strategies have been investigated to optimize and develop ASO for clinical studies. A key objective for this study was to provide an overview of the range of detailed data that get be obtained and provide an updated method review on how to design surfa...

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Literature Corpus work: 3157954a-25bf-5891-9b33-e3b44d26117b
DOI: 10.64898/2026.08.10.743984

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