Article
Twin probes as a novel tool for the detection of single-nucleotide polymorphisms.
Chemistry (Weinheim an der Bergstrasse, Germany) - 3 May 2006
Ergen Erhan, Weber Markus, Jacob Josemon, Herrmann Andreas, Müllen Klaus
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) are the most common form of DNA sequence variation. There is a strong interest from both academy and industry to develop rapid, sensitive and cost effective methods for SNP detection. Here we report a novel structural concept for DNA detection based on fluorescence dequenching upon hybridization. The so-called "twin probe" consists of a central fluorene derivative as...
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