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Article

Detection of DNA oligonucleotides with base mutations by terahertz spectroscopy and microstructures.

PloS one - 1 Jan 2018

Tang Mingjie, Zhang Mingkun, Yan Shihan, Xia Liangping, Yang Zhongbo, Du Chunlei, Cui Hong-Liang, Wei Dongshan

Abstract excerpt

DNA oligonucleotides with a 5-base mutation at the 3'-terminus were investigated by terahertz (THz) spectroscopy in a marker-free manner. The four single-stranded oligonucleotides with 17nt have been detected with specificity on a microfluidic chip, and corroborated by spectral measurements with split-ring resonators. The number of hydrogen bonds formed between the oligonucleotide and its surrounding water...

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PMID: 29364930
DOI: 10.1371/journal.pone.0191515
PMCID: PMC5783420

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