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Article

Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes.

Organic & biomolecular chemistry - 11 Sept 2018

Duprey Jean-Louis H A, Bassani Dario M, Hyde Eva I, Jonusauskas Gediminas, Ludwig Christian, Rodger Alison, Spencer Neil, Vyle Joseph S, Wilkie John, Zhao Zheng-Yun, Tucker James H R

Abstract excerpt

The labelling of DNA oligonucleotides with signalling groups that give a unique response to duplex formation depending on the target sequence is a highly effective strategy in the design of DNA-based hybridisation sensors. A key challenge in the design of these so-called base discriminating probes (BDPs) is to understand how the local environment of the signalling group affects the sensing response. The work...

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PMID: 30168560
DOI: 10.1039/c8ob01710g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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