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Article

Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection.

Nucleic acids research - 30 Sept 2016

Qiu Jieqiong, Wilson Adam, El-Sagheer Afaf H, Brown Tom

Abstract excerpt

A new class of modified oligonucleotides (combination probes) has been designed and synthesised for use in genetic analysis and RNA detection. Their chemical structure combines an intercalating anchor with a reporter fluorophore on the same thymine nucleobase. The intercalator (thiazole orange or benzothiazole orange) provides an anchor, which upon hybridisation of the probe to its target becomes fluorescent and...

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Identifiers

PMID: 27369379
DOI: 10.1093/nar/gkw579
PMCID: PMC5041472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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