Article
Molecular probes: insights into design and analysis from computational and physical chemistry.
Biochemical Society transactions - 1 Feb 2008
Mitchell Felicity L, Marks Gabriel E, Bichenkova Elena V, Douglas Kenneth T, Bryce Richard A
Abstract excerpt
The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluorescence-based molecular probes, HyBeacons, split-probe exciplexes and GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) systems....
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