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Article

Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis.

Cellular signalling - 1 Nov 2005

Kakinuma Hisaya, Inomata Hidehiko, Kitamura Naomi

Abstract excerpt

Nck-interacting kinase-like embryo-specific kinase (NESK) is a protein kinase that is predominantly expressed in skeletal muscle during the late stages of mouse embryogenesis. NESK belongs to the germinal center kinase (GCK) family and selectively activates the c-Jun N-terminal kinase (JNK) pathway when overexpressed in cultured cells. Some members of the GCK family have been shown to be proteolytically cleaved...

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Identifiers

PMID: 15913957
DOI: 10.1016/j.cellsig.2005.03.004

Genes

GCK
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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