Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.

Nature neuroscience - 1 Jul 2007

Muraguchi Teruyuki, Takegami Yujiro, Ohtsuka Toshiyuki, Kitajima Shunsuke, Chandana Ediriweera P S, Omura Akira, Miki Takao, Takahashi Rei, Matsumoto Naoya, Ludwig Andreas, Noda Makoto, Takahashi Chiaki

Abstract excerpt

We report that during cortical development in the mouse embryo, reversion-inducing cysteine-rich protein with Kazal motifs (RECK) critically regulates Notch signaling by antagonizing the ectodomain shedding of Notch ligands, which is mediated by a disintegrin and metalloproteinase domain 10 (ADAM10). In the embryonic brain, RECK is specifically expressed in Nestin-positive neural precursor cells (NPCs)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System

Share to GPI-Linked Proteins

Share to Immunoprecipitation

Share to Luciferases

Share to Receptors, Notch

Share to Retroviridae

Source

Identifiers

PMID: 17558399
DOI: 10.1038/nn1922

Genes

ADAM10
RECK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.PMID 17558399Read ↗

Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele.Semantic proximity Read ↗

RECK Inhibits Stemness Gene Expression and Tumorigenicity of Gastric Cancer Cells by Suppressing ADAM ‐ M ediated Notch1 ActivationSemantic proximity Read ↗

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.Semantic proximity Read ↗

RECK, a novel matrix metalloproteinase regulator.Semantic proximity Read ↗

Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells.Semantic proximity Read ↗

The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.Semantic proximity Read ↗

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.Semantic proximity Read ↗

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.Semantic proximity Read ↗

Mmp17b Is Essential for Proper Neural Crest Cell Migration In VivoSemantic proximity Read ↗

Critical roles for murine Reck in the regulation of vascular patterning and stabilization.Semantic proximity Read ↗

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.Semantic proximity Read ↗

An Overview of Notch Signaling in Adult Tissue Renewal and MaintenanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.