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Article

Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase

18 Oct 2006

Abstract excerpt

BACKGROUND: NARC 1/PCSK9 encodes a novel serine proteinase known to play a role in cholesterol homeostasis. NARC 1 mRNA expression in cerebellar granule neurons (CGNs) was discovered to be induced following an apoptotic injury. Coregulation of known apoptotic mediators (caspase-3 and death receptor 6) raises the possibility that NARC 1 might be involved in the propagation of apoptotic signaling in neurons....

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PMID: 17051583
DOI: 10.1002/cyto.a.20346

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