Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.

The American journal of pathology - 1 Oct 2016

Yanagawa Takayo, Denda Kimitoshi, Inatani Takuya, Fukushima Toshiaki, Tanaka Toshiaki, Kumaki Nobue, Inagaki Yutaka, Komada Masayuki

Abstract excerpt

The onset and/or growth of breast tumor are controlled, at least in part, by estrogen. Therefore, to prevent the development of breast tumor, estrogen-dependent proliferation of mammary epithelial cells during pregnancy needs to be suppressed once the mammary gland is fully developed to enable lactation. However, the underlying molecular mechanisms remain unknown. Nrk is an X-linked protein serine/threonine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogens

Share to Genes, X-Linked

Share to Germinal Center Kinases

Share to Lactation

Share to Mammary Neoplasms, Experimental

Share to MCF-7 Cells

Source

Identifiers

PMID: 27634343
DOI: 10.1016/j.ajpath.2016.06.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.PMID 27634343Read ↗

Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.Semantic proximity Read ↗

A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentasSemantic proximity Read ↗

Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma.Semantic proximity Read ↗

The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair.Semantic proximity Read ↗

Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.Semantic proximity Read ↗

NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis.Semantic proximity Read ↗

Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylationSemantic proximity Read ↗

Deregulated Nras expression in knock-in animals harboring a gammaretroviral long terminal repeat at the Nras/Csde1 locus.Semantic proximity Read ↗

Dynamic Cell Type Specificity of SRC-1 Coactivator in Modulating Uterine Progesterone Receptor Function in MiceSemantic proximity Read ↗

Compromised reproductive function in adult female mice selectively expressing mutant ErbB-1 tyrosine kinase receptors in astroglia.Semantic proximity Read ↗

Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation.Semantic proximity Read ↗

Neuregulin-3 regulates epithelial progenitor cell positioning and specifies mammary phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.