Article
Position specificity of Ki-ras oncogene mutations during the progression of colorectal carcinoma.
Oncology - 1 Jan 1993
Rochlitz C F, Heide I, de Kant E, Böhmer R, Peter F J, Neuhaus P, Huhn D, Herrmann R
Abstract excerpt
The Ki-ras proto-oncogene is converted into an active oncogene by mutations in codon 12, 13, or 61. The incidence of mutations in the Ki-ras oncogene in colorectal adenomas and primary colorectal carcinomas has been shown to be 50-75 and 40-65%, respectively. To determine the role activation of t...
Topics
- Amino Acid Sequence
- Animals
- Codon
- Colorectal Neoplasms
- DNA Mutational Analysis
- Genes, ras
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Mas
- Transplantation, Heterologous