Article
ras gene mutations in human prostate cancer.
Cancer research - 1 Nov 1990
Carter B S, Epstein J I, Isaacs W B
Abstract excerpt
Point mutations at codons 12, 13, or 61 of the Ha-, Ki-, and N-ras genes are able to convert these normal cellular genes into activated oncogenes. Previous studies have shown that ras gene mutations occur in a variety of human solid tumors and may be important in the pathogenesis of some of these tumors. In order to test the hypothesis that ras gene mutations may be associated with prostate cancer, we have used...
Topics
- Adenocarcinoma
- Base Sequence
- DNA, Neoplasm
- Genes, ras
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Prostatic Neoplasms