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Article

The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.

Immunology - 1 Sept 2009

Karabon Lidia, Kosmaczewska Agata, Bilinska Malgorzata, Pawlak Edyta, Ciszak Lidia, Jedynak Anna, Jonkisz Anna, Noga Leszek, Pokryszko-Dragan Anna, Koszewicz Magdalena, Frydecka Irena

Abstract excerpt

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate the association of the CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with the levels of membrane CTLA-4 (mCTLA-4) and cytopl...

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Identifiers

PMID: 19740340
DOI: 10.1111/j.1365-2567.2009.03083.x
PMCID: PMC2753895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19740340-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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