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Article

CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis.

Journal of neuroimmunology - 1 Oct 2002

Mäurer Mathias, Ponath Anke, Kruse Niels, Rieckmann Peter

Abstract excerpt

The cytotoxic T-lymphocyte antigen 4 (CTLA4) is an important modifier of T-cell activation with down-regulatory properties upon B7 engagement. We investigated the association of the CTLA4 A/G dimorphism in exon 1 (+49) with disease susceptibility, disease course and severity. No differences in the allelic distribution of the G(49) allele between multiple sclerosis (MS) patients and the control group was found....

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Source

Identifiers

PMID: 12458055
DOI: 10.1016/s0165-5728(02)00275-8

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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