Article
CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome.
Arthritis research & therapy - 1 Jan 2007
Gottenberg Jacques-Eric, Loiseau Pascale, Azarian Mariam, Chen Chun, Cagnard Nicolas, Hachulla Eric, Puechal Xavier, Sibilia Jean, Charron Dominique, Mariette Xavier, Miceli-Richard Corinne
Abstract excerpt
CTLA-4 encodes cytotoxic T lymphocyte-associated antigen-4, a cell-surface molecule providing a negative signal for T-cell activation. CTLA-4 gene polymorphisms have been widely studied in connection with genetic susceptibility to various autoimmune diseases, but studies have led to contradictory results in different populations. This case-control study sought to investigate whether CTLA-4 CT60 and/or +49A/G...
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