Article
The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.
Nature - 19 May 2005
Youngren Kirsten K, Coveney Douglas, Peng Xiaoning, Bhattacharya Chitralekha, Schmidt Laura S, Nickerson Michael L, Lamb Bruce T, Deng Jian Min, Behringer Richard R, Capel Blanche, Rubin Edward M, Nadeau Joseph H, Matin Angabin
Abstract excerpt
In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129 family of inbred strains, and markedly increases TGCT incidence in 129-Ter/Ter males. In 129-Ter/Ter mice, some of the remaining PGCs transform into undifferentiated pluripotent embryonal carcinoma cells, and after...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.