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Article

The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.

PloS one - 1 Jan 2012

Northrup Emily, Zschemisch Nils-Holger, Eisenblätter Regina, Glage Silke, Wedekind Dirk, Cuppen Edwin, Dorsch Martina, Hedrich Hans-Jürgen

Abstract excerpt

A spontaneous mutation leading to the formation of congenital ovarian and testicular tumors was detected in the WKY/Ztm rat strain. The histological evaluation revealed derivatives from all three germ layers, thereby identifying these tumors as teratomas. Teratocarcinogenesis was accompanied by infertility and the underlying mutation was termed ter. Linkage analysis of 58 (WKY-ter×SPRD-Cu3) F2 rats associated the...

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Source

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Identifiers

PMID: 22655094
DOI: 10.1371/journal.pone.0038001
PMCID: PMC3360017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.PMID 22655094Read ↗

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.Semantic proximity Read ↗

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Loss of Dead end1 induces testicular teratomas from primordial germ cells that failed to undergo sexual differentiation in embryonic testesSemantic proximity Read ↗

Identification of genomic locus responsible for experimentally induced testicular teratoma 1 (ett1) on mouse Chr 18.Semantic proximity Read ↗

Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors.Semantic proximity Read ↗

<i>DMRT1</i> is a testis determining gene in rabbits and is also essential for female fertilitySemantic proximity Read ↗

A Wt1-Dmrt1 Transgene Restores DMRT1 to Sertoli Cells of Dmrt1−/− Testes: A Novel Model of DMRT1-Deficient Germ Cells1Semantic proximity Read ↗

The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.Semantic proximity Read ↗

Search for testicular cancer gene hits dead-end.Semantic proximity Read ↗

DMRT1 is a testis-determining gene in rabbits and is also essential for female fertilitySemantic proximity Read ↗

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