Article
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.
Biology of reproduction - 1 Apr 2021
Ruthig Victor A, Yokonishi Tetsuhiro, Friedersdorf Matthew B, Batchvarova Sofia, Hardy Josiah, Garness Jason A, Keene Jack D, Capel Blanche
Abstract excerpt
In vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or mutation leads to severe PGC loss soon after specification or, in some species, germ cell transformation to somatic lineages. Our investigations into the role of DND1 in PGC specification and differentiation have been limited by...
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