Article

The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish

2022-12-22

Abstract excerpt

The double stranded RNA binding protein Adad1 (adenosine deaminase domain containing 1) is a member of the a denosine d eaminase a cting on R NAs (Adar) protein family with germ cell-specific expression. In mice, Adad1 is necessary for sperm differentiation, however its function outside of mammals has not been investigated. Here, through an N-ethyl-N-nitrosourea (ENU) based forward genetic screen, we identifie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e484a13-f9e8-5bf5-991c-0151c1e703d2
DOI: 10.1101/2022.12.21.521539

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafishDOI 10.1101/2022.12.21.521539Read

ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.Semantic proximity Read

ADR-2 regulates fertility and oocyte fate in <i>C. elegans</i>Semantic proximity Read

<i>Caenorhabditis elegans</i> homologue of the human azoospermia factor <i>DAZ</i> is required for oogenesis but not for spermatogenesisSemantic proximity Read

Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.Semantic proximity Read

DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice.Semantic proximity Read

ADAD2 functions in spermiogenesis and piRNA biogenesis in miceSemantic proximity Read

Zebrafish <i>dazl</i> regulates cystogenesis upstream of the meiotic transition and germline stem cell specification and independent of meiotic checkpointsSemantic proximity Read

A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.Semantic proximity Read

YTHDF2 is essential for spermatogenesis and fertility through mediating a wave of transcript transition during spermatogonial differentiationSemantic proximity Read

The evolutionarily conserved gene Arrdc5 is required for male fertilitySemantic proximity Read

The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of RNP granulesSemantic proximity Read

Whole Transcriptome and Functional Analyses Identify Novel Genes Involved in Meiosis and Fertility in <i>Drosophila melanogaster</i>Semantic proximity Read