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Article

Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2012

Nelson Vicki R, Heaney Jason D, Tesar Paul J, Davidson Nicholas O, Nadeau Joseph H

Abstract excerpt

Environmental agents and genetic variants can induce heritable epigenetic changes that affect phenotypic variation and disease risk in many species. These transgenerational effects challenge conventional understanding about the modes and mechanisms of inheritance, but their molecular basis is poorly understood. The Deadend1 (Dnd1) gene enhances susceptibility to testicular germ cell tumors (TGCTs) in mice, in...

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Source

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Identifiers

PMID: 22923694
DOI: 10.1073/pnas.1207169109
PMCID: PMC3478648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.PMID 22923694Read ↗

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