Article
Mutations in LRRC50 predispose zebrafish and humans to seminomas.
PLoS genetics - 1 Apr 2013
Basten Sander G, Davis Erica E, Gillis Ad J M, van Rooijen Ellen, Stoop Hans, Babala Nikolina, Logister Ive, Heath Zachary G, Jonges Trudy N, Katsanis Nicholas, Voest Emile E, van Eeden Freek J, Medema Rene H, Ketting René F, Schulte-Merker Stefan, Looijenga Leendert H J, Giles Rachel H
Abstract excerpt
Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe the identification of a novel gene predisposing specifically to seminoma formation in a vertebrate model organism. Zebrafish carrying a heterozygous nonsense mutation in Leucine-Rich Repeat Containing protein 50 (lrrc50 also called dnaaf1), associated...
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