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Article

Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.

American journal of physiology. Endocrinology and metabolism - 1 Oct 2005

Hull Rebecca L, Watts Melissah R, Kodama Keiichi, Shen Zhen-ping, Utzschneider Kristina M, Carr Darcy B, Vidal Josep, Kahn Steven E

Abstract excerpt

Genetic background is important in determining susceptibility to metabolic abnormalities such as insulin resistance and beta-cell dysfunction. Islet amyloid is associated with reduced beta-cell mass and function and develops in the majority of our C57BL/6J x DBA/2J (F(1)) male human islet amyloid polypeptide (hIAPP) transgenic mice after 1 yr of increased fat feeding. To determine the relative contribution of...

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PMID: 15899941
DOI: 10.1152/ajpendo.00471.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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