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Article

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

30 Oct 2013

Abstract excerpt

Impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) are polygenic disorders with complex pathophysiologies; recapitulating them with mouse models is challenging. Despite 70% genetic homology, C57BL/6J (BL6) and C57BLKS/J (BLKS) inbred mouse strains differ in response to diet- and genetic-induced obesity. We hypothesized these differences would yield insight into IGT and T2DM susceptibility and response to...

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PMID: 24169046
DOI: 10.1152/ajpendo.00366.2013

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