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Article

High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains.

The Journal of endocrinology - 1 Apr 2017

Hull Rebecca L, Willard Joshua R, Struck Matthias D, Barrow Breanne M, Brar Gurkirat S, Andrikopoulos Sofianos, Zraika Sakeneh

Abstract excerpt

Mouse models are widely used for elucidating mechanisms underlying type 2 diabetes. Genetic background profoundly affects metabolic phenotype; therefore, selecting the appropriate model is critical. Although variability in metabolic responses between mouse strains is now well recognized, it also occurs within C57BL/6 mice, of which several substrains exist. This within-strain variability is poorly understood and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28138002
DOI: 10.1530/JOE-16-0377
PMCID: PMC5358546

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