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Article

Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.

Human molecular genetics - 15 Nov 2003

Lehman Emily J H, Kulnane Laura Shapiro, Gao Yuan, Petriello Michelle C, Pimpis Karen M, Younkin Linda, Dolios Georgia, Wang Rong, Younkin Steven G, Lamb Bruce T

Abstract excerpt

Alzheimer's disease (AD) is a multigenic neurodegenerative disorder characterized by distinct neuropathological hallmarks including deposits of the beta-amyloid (A beta) peptide. A beta is a 39- to 43-amino acid peptide derived from the proteolytic processing of the amyloid precursor protein (APP). While increasing evidence suggests that altered APP processing and A beta metabolism is a common feature of AD, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14506131
DOI: 10.1093/hmg/ddg322

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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