Article
The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.
Diabetologia - 1 Jan 2003
Vidal J, Verchere C Bruce, Andrikopoulos S, Wang F, Hull R L, Cnop M, Olin K L, LeBoeuf R C, O'Brien K D, Chait A, Kahn S E
Abstract excerpt
AIMS/HYPOTHESIS: Islet amyloid deposits are present in over 85% of Type 2 diabetic patients and have been suggested to be pathogenic. The mechanism that converts islet amyloid polypeptide (IAPP), the unique component of these deposits, into amyloid fibrils in vivo is not known. The amino acid sequence of IAPP is critical but insufficient for beta-pleated sheet formation. As apolipoprotein E (apoE), another...
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