Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

doi:10.1158/1055-9965.EPI-04-0501

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2005

Zhang Zhengdong, Shi Qiuling, Liu Zhensheng, Sturgis Erich M, Spitz Margaret R, Wei Qingyi

Abstract excerpt

Although tobacco and alcohol use are the major risk factors, folate deficiency has been implicated in the risk of squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) in the folate metabolic pathway are associated with SCCHN risk. In a hospital-based case-control study of 721 SCCHN cases and 1,234 controls of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcohol Drinking

Share to Carcinoma, Squamous Cell

Share to Ferredoxin-NADP Reductase

Share to Head and Neck Neoplasms

Share to Interviews as Topic

Share to Logistic Models

Share to Texas

Source

Open in PubMed

Identifiers

PMID: 15894670
DOI: 10.1158/1055-9965.EPI-04-0501

Genes

MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.PMID 15894670Read ↗

Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.Semantic proximity Read ↗

One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.Semantic proximity Read ↗

Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk.Semantic proximity Read ↗

5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer.Semantic proximity Read ↗

Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis.Semantic proximity Read ↗

Head and neck cancer: genetic polymorphisms and folate metabolism.Semantic proximity Read ↗

Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer.Semantic proximity Read ↗

Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population.Semantic proximity Read ↗

MTHFD1 G1958A, BHMT G742A, TC2 C776G and TC2 A67G polymorphisms and head and neck squamous cell carcinoma risk.Semantic proximity Read ↗

DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.Semantic proximity Read ↗

Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.