Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2004

Zhang Zhengdong, Shi Qiuling, Sturgis Erich M, Spitz Margaret R, Hong Waun Ki, Wei Qingyi

Abstract excerpt

PURPOSE: Folate deficiency and reduced DNA repair capacity are established risk factors for squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk. EXPERIMENTAL DESIGN: In a hospital-based case-control study of 704 SCCHN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to 5' Untranslated Regions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Carcinoma, Squamous Cell

Share to Disease Progression

Share to Head and Neck Neoplasms

Share to Smoking

Share to Thymidylate Synthase

Source

Identifiers

PMID: 15585623
DOI: 10.1158/1078-0432.CCR-04-0923

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck.PMID 15585623Read ↗

Case-control analysis of thymidylate synthase polymorphisms and risk of lung cancerSemantic proximity Read ↗

Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.Semantic proximity Read ↗

Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis.Semantic proximity Read ↗

Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.Semantic proximity Read ↗

The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis.Semantic proximity Read ↗

Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.Semantic proximity Read ↗

Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.Semantic proximity Read ↗

Tyms double (2R) and triple repeat (3R) confers risk for human oral squamous cell carcinoma.Semantic proximity Read ↗

Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis.Semantic proximity Read ↗

The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

2R of thymidylate synthase 5'-untranslated enhanced region contributes to gastric cancer risk: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.