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Article

Differences in regional brain atrophy in genetic forms of Alzheimer's disease.

Neurobiology of aging - 1 Mar 2006

Gregory Gillian C, Macdonald Virginia, Schofield Peter R, Kril Jillian J, Halliday Glenda M

Abstract excerpt

Multiple degenerative hallmarks characterize Alzheimer's disease: insoluble protein deposition, neuronal loss and cortical atrophy. Atrophy begins in the medial temporal lobe and becomes global by end stage. In a small proportion of cases, these tissue changes are caused by mutations in three known genes. These cases are affected earlier in life and have more abundant protein deposition, which may indicate...

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PMID: 15894410
DOI: 10.1016/j.neurobiolaging.2005.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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