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Anatomical progression of genetic frontotemporal lobar degeneration across the lifespan

25 May 2025

Abstract excerpt

The recent development of brain charts for the human lifespan offers an ideal modelling framework for pathologies such as genetic frontotemporal lobar degeneration (FTLD) which likely involve both neurodevelopmental and neurodegenerative processes over a lifetime. We have therefore combined this new methodological approach with MRI data from asymptomatic and symptomatic subjects, carrying C9orf72, MAPT or GRN...

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PMID: 40424598
DOI: 10.1093/brain/awaf195

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