Article
Genetic influences on atrophy patterns in familial Alzheimer's disease: a comparison of APP and PSEN1 mutations.
Journal of Alzheimer's disease : JAD - 1 Jan 2013
Scahill Rachael I, Ridgway Gerard R, Bartlett Jonathan W, Barnes Josephine, Ryan Natalie S, Mead Simon, Beck Jonathan, Clarkson Matthew J, Crutch Sebastian J, Schott Jonathan M, Ourselin Sebastien, Warren Jason D, Hardy John, Rossor Martin N, Fox Nick C
Abstract excerpt
Mutations in the presenilin1 (PSEN1) and amyloid β-protein precursor (APP) genes account for the majority of cases of autosomal dominantly inherited Alzheimer's disease (AD). We wished to assess and compare the patterns of cerebral loss produced by these two groups of mutations. Volumetric magnetic resonance imaging and neuropsychological assessments were performed in individuals with clinical AD carrying...
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