Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations.

doi:10.1016/j.neuroimage.2009.12.088

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Article

Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations.

NeuroImage - 15 Nov 2010

Rohrer Jonathan D, Ridgway Gerard R, Modat Marc, Ourselin Sebastien, Mead Simon, Fox Nick C, Rossor Martin N, Warren Jason D

Abstract excerpt

Neural network breakdown is a key issue in neurodegenerative disease, but the mechanisms are poorly understood. Here we investigated patterns of brain atrophy produced by defined molecular lesions in the two common forms of genetically mediated frontotemporal lobar degeneration (FTLD). Nine patients with progranulin (GRN) mutations and eleven patients with microtubule-associated protein tau (MAPT) mutations had...

Topics

Aged
Atrophy
Brain
Brain Mapping
Female
Frontotemporal Lobar Degeneration
Genotype
Humans
Image Interpretation, Computer-Assisted
Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Male

Middle Aged

Mutation

Phenotype

Progranulins

tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20045477
DOI: 10.1016/j.neuroimage.2009.12.088
PMCID: PMC2941039

Genes

GRN
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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