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Article

Clinical phenotypes of Alzheimer's disease: investigating atrophy patterns and their pathological correlates.

Alzheimer's research & therapy - 26 Apr 2025

Reijner Niels, Frigerio I, Bouwman M M A, Boon B D C, Guizard N, Jubault T, Hoozemans J J M, Rozemuller A J M, Bouwman F H, Barkhof F, Gordon E, van de Berg W D J, Jonkman L E

Abstract excerpt

BACKGROUND: In Alzheimer's disease (AD), MRI atrophy patterns can distinguish between amnestic (typical) and non-amnestic (atypical) clinical phenotypes and are increasingly used for diagnosis and outcome measures in clinical trials. However, understanding how protein accumulation and other key features of neurodegeneration influence these imaging measurements, are lacking. The current study aimed to assess...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40281562
DOI: 10.1186/s13195-025-01727-5
PMCID: PMC12032798

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