Article
Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.
Leukemia - 1 Apr 1992
Fenaux P, Preudhomme C, Laï J L, Quiquandon I, Jonveaux P, Vanrumbeke M, Sartiaux C, Morel P, Loucheux-Lefebvre M H, Bauters F
Abstract excerpt
Mutations of exons 5 to 8 of the p53 gene were looked for in 39 cases of B-cell chronic lymphocytic leukemia (CLL) using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing. All patients also had cytogenetic analysis. A point mutation, leading to an amino acid change in the p53 protein was found in four cases, involving exon 7 (one case) or exon 8 (three cases). Mutations...
Topics
- Aged
- Chromosomes, Human, Pair 17
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA, Single-Stranded
- Exons
- Female
- Genes, p53
- Humans
- Karyotyping
- Leukemia, Lymphocytic, Chronic, B-Cell