Article
Tumor Protein 53 Gene Mutations Without 17p13 Deletion Have No Significant Clinical Implications in Chronic Lymphocytic Leukemia. Detection of a New Mutation.
Anticancer research - 1 May 2017
Diamantopoulos Panagiotis T, Samara Stavroula, Kollia Panagoula, Giannakopoulou Nefeli, Sofotasiou Maria, Kalala Fani, Kodandreopoulou Elina, Zervakis Panagiotis, Vassilakopoulos Theodoros, Siakantaris Marina, Mantzourani Marina, Angelopoulou Maria, Kyrtshonis Marie-Christine, Korkolopoulou Penelope, Patsouris Efstathios, Viniou Nora-Athina
Abstract excerpt
BACKGROUND: The tumor protein p53 (TP53) gene may be inactivated through 17p13 deletion, somatic mutations, or both. In chronic lymphocytic leukemia (CLL) although 17p13 deletion is correlated with poor prognosis, the role of sole TP53 mutations remains controversial. MATERIALS AND METHODS: We carried out a mutation analysis of TP53 gene in 72 patients with CLL. RESULTS: Seventy-one (98.6%) patients carried the...
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