Article
TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia.
Leukemia research - 1 Feb 2011
Zainuddin Norafiza, Murray Fiona, Kanduri Meena, Gunnarsson Rebeqa, Smedby Karin E, Enblad Gunilla, Jurlander Jesper, Juliusson Gunnar, Rosenquist Richard
Abstract excerpt
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of...
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