Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterisation of TP53 abnormalities in chronic lymphocytic leukaemia.

The hematology journal : the official journal of the European Haematology Association - 1 Jan 2004

Thornton Patrick D, Gruszka-Westwood Alicja M, Hamoudi Rifat A, Atkinson Shayne, Kaczmarek Pawel, Morilla Ricardo M, Hilditch Benjamin L, A'Hern Roger, Matutes Estella, Catovsky Daniel

Abstract excerpt

Abnormalities of TP53 in chronic lymphocytic leukaemia (CLL) correlate with aggressive disease and transformation. We studied 115 patients with CLL including 90 untreated, 25 with heavily pretreated/refractory CLL using fluorescent in situ hybridisation (FISH) to detect allelic loss at chromosome 17p and flow cytometry (FC) to test p53 protein overexpression. A total of 17 cases were identified with TP53 deletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Prognosis

Share to Proportional Hazards Models

Share to Survival Analysis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 14745430
DOI: 10.1038/sj.thj.6200325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterisation of TP53 abnormalities in chronic lymphocytic leukaemia.PMID 14745430Read ↗

Relevance of TP53 for CLL diagnosticsSemantic proximity Read ↗

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up.Semantic proximity Read ↗

The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype.Semantic proximity Read ↗

The clinical implications of gene mutations in chronic lymphocytic leukaemia.Semantic proximity Read ↗

Complex TP53 Alterations with del(17p) and del(13q) in Chronic Lymphocytic Leukemia: Clinical Implications from a Case-Based Review.Semantic proximity Read ↗

Gene mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

TP53 mutations are early events in chronic lymphocytic leukemia disease progression and precede evolution to complex karyotypes.Semantic proximity Read ↗

ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia.Semantic proximity Read ↗

Genetic alterations in chronic lymphocytic leukaemia.Semantic proximity Read ↗

Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damageSemantic proximity Read ↗

Patients with chronic lymphocytic leukaemia and clonal deletion of both 17p13.1 and 11q22.3 have a very poor prognosisSemantic proximity Read ↗

Molecular and transcriptional characterization of 17p loss in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.