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Article

p53 abnormalities in B-cell prolymphocytic leukemia.

Blood - 15 Mar 1997

Lens D, De Schouwer P J, Hamoudi R A, Abdul-Rauf M, Farahat N, Matutes E, Crook T, Dyer M J, Catovsky D

Abstract excerpt

B-cell prolymphocytic leukemia (B-PLL) is an aggressive disorder of mature B cells with distinct clinical and pathologic features. To determine the incidence of abnormalities of p53, we analyzed 19 cases of B-PLL by DNA blot to assess loss of heterozygosity (LOH) at 17p13.3, by immunocytochemistry to assess p53 expression, and by direct DNA sequencing of polymerase chain reaction-amplified exons 5 to 9 of the p53...

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PMID: 9058723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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