Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.

Gastroenterology - 1 May 2005

Ishimura Norihisa, Bronk Steven F, Gores Gregory J

Abstract excerpt

BACKGROUND & AIMS: Inflammatory mediators and cell fate genes, such as the Notch gene family, both have been implicated in cancer biology. Because cholangiocarcinomas arise in a background of inflammation and express the inflammatory mediator inducible nitric oxide synthase (iNOS), we aimed to determine whether iNOS expression alters Notch expression and signaling. METHODS: Notch receptor and ligand expression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Bile Duct Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts

Share to Cholangitis, Sclerosing

Share to Mitogen-Activated Protein Kinase 8

Share to Nitric Oxide Donors

Share to Nitric Oxide Synthase Type II

Share to Receptor, Notch1

Source

Identifiers

PMID: 15887117
DOI: 10.1053/j.gastro.2005.01.055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.PMID 15887117Read ↗

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.Semantic proximity Read ↗

Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In VivoSemantic proximity Read ↗

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytesSemantic proximity Read ↗

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humansSemantic proximity Read ↗

A Critical Role for Notch Signaling in the Formation of Cholangiocellular CarcinomasSemantic proximity Read ↗

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver diseaseSemantic proximity Read ↗

Endogenous interferon gamma protects against cholestatic liver injury in mice.Semantic proximity Read ↗

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in miceSemantic proximity Read ↗

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype.Semantic proximity Read ↗

Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice†‡Semantic proximity Read ↗

Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasisSemantic proximity Read ↗

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.