Article

Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis

2020-03-26

Abstract excerpt

The inflammatory response plays an important role in cholestatic liver injury where bile acid (BA) induction of proinflammatory cytokines in hepatocytes is an initial pathophysiologic event. However, the signaling pathways involving BA stimulation of cytokine production remain to be elucidated. In this report, we examined the functional role of the Nuclear Factor of Activated T-cells (NFAT) in BA-induction of infl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2db8bf3-b382-581a-ad6c-9f36c884a14b
DOI: 10.1101/2020.03.25.007831

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasisDOI 10.1101/2020.03.25.007831Read

Molecular mechanism of cholangiocarcinoma carcinogenesis.Semantic proximity Read

Epigenetic Alterations in Cholangiocarcinoma-Sustained IL-6/STAT3 Signaling in Cholangio- carcinoma due to SOCS3 Epigenetic SilencingSemantic proximity Read

Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expressionSemantic proximity Read

Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.Semantic proximity Read

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesisSemantic proximity Read

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasisSemantic proximity Read

Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.Semantic proximity Read

Galectin-3 in Inflammasome Activation and Primary Biliary Cholangitis Development.Semantic proximity Read

Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasisSemantic proximity Read

miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene NfibSemantic proximity Read

Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.Semantic proximity Read

Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation.Semantic proximity Read