Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans

5 Dec 2016

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is a rare yet deadly malignancy with limited treatment options. Activation of the Notch signalling cascade has been implicated in cholangiocarcinogenesis. However, while several studies focused on the Notch receptors required for ICC development, little is known about the upstream inducers responsible for their activation. Here, we show that the Jagged 1 (Jag1) ligand is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27918553
DOI: 10.1038/oncsis.2016.73

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humansPMID 27918553Read ↗

Cholangiocarcinomas can originate from hepatocytes in miceSemantic proximity Read ↗

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in miceSemantic proximity Read ↗

Oncogenic role of the Notch pathway in primary liver cancerSemantic proximity Read ↗

A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor ProgressionSemantic proximity Read ↗

Role of the Notch signaling in cholangiocarcinomaSemantic proximity Read ↗

Simultaneous activation of Kras–Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathwaySemantic proximity Read ↗

Expression of transforming growth factor β1 promotes cholangiocarcinoma development and progressionSemantic proximity Read ↗

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytesSemantic proximity Read ↗

A novel mouse model of cholangiocarcinoma uncovers a role for a SOX17-Tensin 4 pathway in tumor progressionSemantic proximity Read ↗

Oncogenic driver genes and tumor microenvironment determine the type of liver cancerSemantic proximity Read ↗

AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progressionSemantic proximity Read ↗

AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.