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Article

Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo

30 Oct 2013

Abstract excerpt

UNLABELLED: Cholangiocacinoma (CC) is a cancer disease with rising incidence. Notch signaling has been shown to be deregulated in many cancers. However, the role of this signaling pathway in the carcinogenesis of CC is still not fully explored. In this study, we investigated the effects of Notch inhibition by γ-secretase inhibitor IX (GSI IX) in cultured human CC cell lines and we established a transgenic mouse...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 24204826
DOI: 10.1371/journal.pone.0077433

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