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Article

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype.

The Biochemical journal - 1 Oct 2012

Chou Ming-Huei, Huang Ying-Hsien, Lin Tsun-Mei, Du Yung-Ying, Tsai Po-Chin, Hsieh Chih-Sung, Chuang Jiin-Haur

Abstract excerpt

Cholestatic liver injury may activate HSCs (hepatic stellate cells) to a profibrogenic phenotype, contributing to liver fibrogenesis. We have previously demonstrated the involvement of TLR (Toll-like receptor) 7 in the pathogenesis of biliary atresia. In the present study we investigated the ability of TLR7 to modulate the profibrogenic phenotype in HSCs. Obstructive jaundice was associated with significant...

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Source

Identifiers

PMID: 22765640
DOI: 10.1042/BJ20112058

Genes

TLR7
TLR8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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