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Article

Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice†‡

19 Feb 2005

Abstract excerpt

The discovery that the human Jagged1 gene (JAG1) is the Alagille syndrome disease gene indicated that Notch signaling has an important role in bile duct homeostasis. The functional study of this signaling pathway has been difficult because mice with targeted mutations in Jagged1, Notch1, or Notch2 have an embryonic lethal phenotype. We have previously generated mice with inducible Notch1 disruption using an...

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PMID: 15723439
DOI: 10.1002/hep.20571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice†‡PMID 15723439Read ↗

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Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopySemantic proximity Read ↗

Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signalingSemantic proximity Read ↗

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